Possible mechanisms of prednisolone-induced osteoporosis in zebrafish larva
نویسندگان
چکیده
منابع مشابه
the effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
background: objective: it was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. materials and methods: bone mineral density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (alp) measurements were performed. o...
متن کاملThe effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
BACKGROUND Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. OBJECTIVE It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. MATERI...
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Glucocorticoids modify osteoblastic cell differentiation, number, and function. Glucocorticoids stimulate osteoclastogenesis and increase the expression of receptor activator of Nuclear factor-kappaB ligand and colony-stimulating factor-1, and decrease the expression of osteoprotegerin. However, the most significant effect of glucocorticoids in bone is an inhibition of bone formation. This inhi...
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Background Varicocele (VCL) is characterized by a progressive disorder which is defined by tortuosity of the pampiniform plexus veins that exerts bilateral impacts. 50-60 percent of males with infertility problems are suffering from VCL. Considering VCL-induced massive problems in human fertilizing potential, investigating different aspects of VCL-induced derangements is gaining considerable at...
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Drug-induced osteoporosis is common and has a significant impact on the prognosis of patients suffering from chronic debilitating diseases. Glucocorticoids are the drugs causing osteoporotic fractures most frequently, but osteoporosis with fractures is observed also in women treated with aromatase inhibitors for breast cancer, in men receiving anti-androgen therapy for prostate cancer, in postm...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2018
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2018.02.082